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Continuing Education in Anaesthesia, Critical Care & Pain | Volume 4 Number 3 2004 © The Board of Management and Trustees of the British Journal of Anaesthesia 2004

Hypertension: pathophysiology and treatment

P Foëx, DPhil FRCA FMedSci, Emeritus Nuffield Professor of Anaesthetics
Nuffield Department of Anaesthetics, The John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU

JW Sear, PhD FRCA, Professor of Anaesthetics
Nuffield Department of Anaesthetics, The John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU
Tel: 01865 851138, Fax: 01865 220027, E-mail: pierre.foex{at}nda.ox.ac.uk (for correspondence)

Arterial hypertension is a major cause of morbidity and mortality because of its association with coronary heart disease, cerebrovascular disease and renal disease. The extent of target organ involvement (i.e. heart, brain and kidneys) determines outcome. North American studies have shown that hypertension is a major contributor to 500 000 strokes (250 000 deaths) and 1 000 000 myocardial infarctions (500 000 deaths) per annum.


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