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Continuing Education in Anaesthesia, Critical Care & Pain 2004 4(6):181-184; doi:10.1093/bjaceaccp/mkh049
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Continuing Education in Anaesthesia, Critical Care & Pain | Volume 4 Number 6 2004 © The Board of Management and Trustees of the British Journal of Anaesthesia 2004

Drugs and receptors

DG Lambert, BSc (Hons) PhD, Reader in Anaesthetic Pharmacology, Edmund Riding Professor of Anaesthesia
The Royal College of Anaesthetists, University Division of Anaesthesia, Critical Care and Pain Management & Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester, LE1 5WW
Tel: 01162 585 694, Fax: 01162 854 487, E-mail: dgl3{at}le.ac.uk

There are four principle protein targets with which drugs can interact: enzymes (e.g. neostigmine and acetyl cholinesterase), membrane carriers (e.g. tricyclic antidepressants and catecholamine uptake-1), ion channels (e.g. nimodipine and voltage-gated Ca2+ channels) and receptors. This article is concerned with the receptor and describes the dynamics of drug–receptor interaction, agonists, antagonists, partial agonists and inverse agonists, efficacy and potency. Key definitions are shown in Table 1.


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  		Table 1 Key definitions

 

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