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Continuing Education in Anaesthesia Critical Care and Pain | Volume 4 Number 1 | 2004
© The Board of Management and Trustees of the British Journal of Anaesthesia 2004

Multiple Choice Answers

The first 150 words of the full text of this article appear below.

  1. The duration of action of non-depolarizing neuromuscular blocking drugs may be prolonged by:
    (a) True; (b) True; (c) True; (d) True; (e) True
    (a, b, e) Amitriptyline and other tricyclic antidepressants potentiate the action of non-depolarizing blocking drugs by closed-channel block, whereas verapamil and lidocaine do so by an open-channel block mechanism. (c) Reduced clearance of the neuromuscular blocking drugs during hypothermia prolongs their duration of action, probably because of decreased enzyme activity. (d) Acidosis prolongs the duration of action of neuromuscular blocking drugs.
  2. Succinylcholine:
    (a) True; (b) False; (c) False; (d) False; (e) False
    (a) In contrast to its action at cardiac muscarinic receptors, the effect of succinylcholine at ganglionic nicotinic receptors may produce increases in heart rate and blood pressure. (b) Succinylcholine is metabolized by plasma cholinesterase, not acetylcholinesterase. (c) Neostigmine and other anticholinesterases prolong the action of succinylcholine by inhibiting plasma cholinesterase. (d) The rise in serum . . . [Full Text of this Article]


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