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Continuing Education in Anaesthesia, Critical Care & Pain 2006 6(4):141-143; doi:10.1093/bjaceaccp/mkl027
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Continuing Education in Anaesthesia, Critical Care & Pain | Volume 6 Number 4 2006 © The Board of Management and Trustees of the British Journal of Anaesthesia [2006]. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Rhabdomyolysis

John D Hunter, DIC FRCA
Consultant in Anaesthetics and Intensive Care, Macclesfield District General Hospital Victoria Road, Macclesfield, Cheshire, SK10 3BL, UK Tel: 01625 661307, Fax: 01625 663209, E-mail: john.hunter@echeshire-tr.nwest.nhs.uk

Katy Gregg, MBBS BMEDSCI
Specialist Registrar in Anaesthetics, Macclesfield District General Hospital Macclesfield, UK

Zaherali Damani, FCARCSI
Specialist Registrar in Anaesthetics, University Hospital Aintree, Aintree Hospitals NHS Trust Lower Lane, Liverpool, L9 7AL, UK
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Key points

Rhabdomyolysis describes the destruction or disintegration of striated muscle; it is an important cause of acute renal failure.

Creatinine kinase concentration is the most sensitive and useful indicator of muscle injury in rhabdomyolysis.

The most important intervention is early aggressive crystalloid fluid resuscitation.

Life-threatening hyperkalaemia is a common cause of death and must be treated promptly.

Myoglobin-induced renal failure has an excellent prognosis.

 

The term rhabdomyolysis describes the breakdown or disintegration of striated muscle. Although a broad range of conditions can result in rhabdomyolysis, the final common pathway of myocyte necrosis involves a rapid increase in intracytoplasmic calcium. This leads to the release of myocyte constituents into the circulation, which can produce life-threatening complications including acute hyperkalaemia and acute renal failure (ARF).

Rhabdomyolysis is a common cause of ARF, especially in times of conflict or after major disasters . . . [Full Text of this Article]


   Causes
 

   Pathophysiology
 

   Clinical Presentation
 

   Metabolic Derangements
 

   Biochemical Markers
 

   Acute Renal Failure
 

   Management
 

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