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Continuing Education in Anaesthesia, Critical Care & Pain 2006 6(2):93-96; doi:10.1093/bjaceaccp/mkl011
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Continuing Education in Anaesthesia, Critical Care & Pain | Volume 6 Number 2 2006 © The Board of Management and Trustees of the British Journal of Anaesthesia [2006]. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Multiple Choice Answers

The first 150 words of the full text of this article appear below.

1. Regarding general anaesthetic activity:
(a) False; (b) False; (c) True; (d) False; (e) True
(b) General anaesthetics are structurally diverse and show no obvious structure–activity relationships. (b,e) Current consensus states that certain general anaesthetics target proteins within the central nervous system in a highly stereoselective manner rather than globally perturbing neuronal membranes. (c) Most general anaesthetics are relatively soluble in olive oil. (d) Lipid bilayers are composed of a diverse and dynamic mixture of lipid, protein, and carbohydrates.
2. On possible targets of general anaesthetics:
(a) False; (b) True; (c) False; (d) True; (e) False
(b) Although transmitter-gated ion channels are likely targets for general anaesthetics many other proteins within the central nervous system might be responsible for their range of clinical effects. (b,c,d) In general, 5-HT3 and neuronal nicotinic receptors mediate fast excitatory neurotransmission, whereas GABAA and glycine receptors mediate fast inhibitory neurotransmission. (e) GABAB receptors are relatively . . . [Full Text of this Article]


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