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Continuing Education in Anaesthesia, Critical Care & Pain Advance Access published online on January 3, 2006
Continuing Education in Anaesthesia, Critical Care & Pain, doi:10.1093/bjaceaccp/mki068
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Continuing Education in Anaesthesia, Critical Care & Pain © The Board of Management and Trustees of the British Journal of Anaesthesia [2005]. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Article

The molecular mechanisms of general anaesthesia: dissecting the GABAA receptor

Cameron J. Weir BSc(Hons) FRCA PhD 1 *
1 Consultant Anaesthetist/Senior Lecturer, Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK

* To whom correspondence should be addressed.
Cameron J. Weir, E-mail: c.j.weir{at}dundee.ac.uk


  Abstract

The mechanisms underlying the dramatic clinical effects of general anaesthetics remain elusive. This review summarizes the remarkable developments which have occurred in general anaesthetic research over the past decade demonstrating that, rather than acting nonspecifically to disrupt lipid membranes, general anaesthetics target certain CNS proteins in a highly selective manner.


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